什么是GEO数据库？2024年基因表达综合数据库功能详解

Introduction

The Gene Expression Omnibus (GEO) is a critical public repository for the scientific community, managed by the National Center for Biotechnology Information (NCBI). It serves as a central hub for storing and sharing high-throughput functional genomics data, which is essential for advancing research in fields like molecular biology, medicine, and biotechnology.

基因表达综合数据库（GEO）是由美国国家生物技术信息中心（NCBI）管理的一个对科学界至关重要的公共数据库。它作为一个存储和共享高通量功能基因组学研究基因组中基因功能及其相互作用的学科领域，关注基因表达、调控和功能分析。数据的中心枢纽，对于推动分子生物学、医学和生物技术等领域的研究至关重要。

What is GEO?

GEO is a public functional genomics data repository supporting MIAME-compliant data submissions. Array- and sequence-based data are accepted. Tools are provided to help users query and download experiments and curated gene expression profiles.

GEO 是一个公共功能基因组学研究基因组中基因功能及其相互作用的学科领域，关注基因表达、调控和功能分析。数据存储库专门用于存储、管理和共享科学数据的在线数据库系统，通常遵循特定的数据标准和格式。，支持符合 MIAME 标准的数据提交。它接受基于芯片和测序的数据。该平台提供了多种工具，帮助用户查询和下载实验数据以及经过整理的基因表达谱在特定条件下，细胞或组织中所有基因表达水平的综合图谱，反映基因的活跃状态。。

Key Features and Access

The GEO platform is designed with both data submitters and users in mind. Its structure facilitates easy navigation and data retrieval.

GEO 平台的设计兼顾了数据提交者和用户的需求。其结构便于轻松导航和数据检索。

Getting Started: Guides for new users to understand how to access and utilize the database effectively.
- 入门指南：为新用户提供指导，帮助他们了解如何有效地访问和使用该数据库。
Tools: A suite of applications and utilities for analyzing, visualizing, and downloading datasets.
- 工具：一套用于分析、可视化和下载数据集的应用程序和实用工具。
Browse Content: Allows users to explore datasets by organism, technology type, or study characteristics.
- 浏览内容：允许用户按生物体、技术类型或研究特征浏览数据集。
Information for Submitters: Detailed guidelines and protocols for researchers to submit their own datasets to the repository, ensuring data quality and consistency.
- 提交者信息：为研究人员向存储库提交自己的数据集提供详细的指南和协议，确保数据质量和一致性。

The Importance of Data Standards (MIAME)

A cornerstone of GEO's utility is its adherence to the Minimum Information About a Microarray Experiment (MIAME) standard. This compliance ensures that submitted datasets are accompanied by sufficient experimental detail to allow for their accurate interpretation, independent verification, and meaningful re-analysis by other researchers. This standard fosters reproducibility and data reuse in genomics research.

GEO 实用性的一个基石是它遵循微阵列实验最小信息（MIAME）标准。这种合规性确保提交的数据集附有足够的实验细节，以便其他研究人员能够进行准确的解释、独立验证和有意义的重新分析。这一标准促进了基因组学研究的可重复性和数据重用。

Conclusion

The Gene Expression Omnibus is more than just an archive; it is a foundational resource that empowers open science. By providing free access to a vast and growing collection of functional genomics data along with powerful analysis tools, GEO accelerates discovery and collaboration across the global life sciences community.

基因表达综合数据库（GEO）不仅仅是一个档案库；它是一个赋能开放科学的基础性资源。通过免费提供大量且不断增长的功能基因组学研究基因组中基因功能及其相互作用的学科领域，关注基因表达、调控和功能分析。数据以及强大的分析工具，GEO 加速了全球生命科学界的发现和协作。